Harmine (hydrochloride) (Standard)
Harmine Hydrochloride (Telepathine Hydrochloride) is a natural DYRK inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM[1].
Product Specifications
CAS Number
343-27-1
Product Name Alternative
Telepathine (hydrochloride) (Standard)
UNSPSC
12352005
Target
5-HT Receptor; DYRK
Related Pathways
GPCR/G Protein; Neuronal Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer; Neurological Disease
Smiles
CC1=NC=CC2=C1NC3=C2C=CC(OC)=C3.Cl
Molecular Formula
C13H13ClN2O
Molecular Weight
248.71
References & Citations
[1] Glennon RA, et al. Binding of beta-carbolines and related agents at serotonin (5-HT (2) and 5-HT (1A) ), dopamine (D (2) ) and benzodiazepine receptors. Drug Alcohol Depend. 2000 Aug 1;60 (2) :121-32.|[2]Neumann F, et al. DYRK1A inhibition and cognitive rescue in a Down syndrome mouse model are induced by new fluoro-DANDY derivatives. Sci Rep. 2018 Feb 12;8 (1) :2859.|[3] Zhang L, et al. Harmine suppresses homologous recombination repair and inhibits proliferation of hepatoma cells. Cancer Biol Ther. 2015;16 (11) :1585-92.|[4]Zhong Z, et al. Treatment with harmine ameliorates functional impairment and neuronal death following traumatic brain injury. Mol Med Rep. 2015 Dec;12 (6) :7985-91.
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Room temperature
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