Licarin B-d4

Licarin B-d4 is the deuterium labeled Licarin B (HY-N0479) . Licarin B, a nitric oxide production inhibitor extracted from the component of the seeds of Myristica fragrans, improves insulin sensitivity via PPARγ and activation of GLUT4 in the IRS-1/PI3K/AKT pathway[1][2][3].

Product Specifications

UNSPSC

12352005

Target

GLUT; Isotope-Labeled Compounds; PPAR

Related Pathways

Cell Cycle/DNA Damage; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor

Field of Research

Metabolic Disease

Smiles

COC1=C(O[C@@H](C2=CC=C3C(OCO3)=C2)[C@@H]4C)C4=CC(/C=C([2H])/C([2H])([2H])[2H])=C1

Molecular Formula

C20H16D4O4

Molecular Weight

328.40

References & Citations

[1]Kim YB, et al. The crystal structure of licarin-B, (C20H20O4), a component of the seeds of Myristica fragrans. Arch Pharm Res. 1991 Mar;14 (1) :1-6. |[2]G. L. Shyni, et al. Licarin B from Myristica fragrans improves insulin sensitivity via PPARγ and activation of GLUT4 in the IRS-1/PI3K/AKT pathway in 3T3-L1 adipocytes. RSC Adv. 2016.|[3]Cao GY, et al. New inhibitors of nitric oxide production from the seeds of Myristica fragrans. Food Chem Toxicol. 2013 Dec;62:167-71.