D-Mannitol, M100 (GMP Like)

D-Mannitol, M100 (GMP Like) (Mannitol, M100 (GMP Like) ) is the GMP Like class D-Mannitol that can be used as pharmaceutical excipients. D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β3-adrenergic receptor (β3-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells[1][2][3][4][5][6][7].

Product Specifications

CAS Number

[69-65-8]

Product Name Alternative

Mannitol, M100 (GMP Like) ; Mannite, M100 (GMP Like)

UNSPSC

12352211

Target

Adrenergic Receptor; Apoptosis; Endogenous Metabolite; PGC-1α; PKA

Related Pathways

Apoptosis; GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling; Stem Cell/Wnt; TGF-beta/Smad

Field of Research

Cancer; Metabolic Disease; Cardiovascular Disease

Smiles

OC[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O

Molecular Formula

C6H14O6

Molecular Weight

182.17

References & Citations

[1]Tan, K., et al., The mannitol operon repressor MtlR belongs to a new class of transcription regulators in bacteria. J Biol Chem, 2009. 284 (52) : p. 36670-9. |[2]Nishiyama, A., et al., Mannitol lowers fat digestibility and body fat accumulation in both normal and cecectomized rats. J Nutr Sci Vitaminol (Tokyo), 2009. 55 (3) : p. 242-51.|[3]Hanieh, H. and E. Sakaguchi, Effect of D-mannitol on feed digestion and cecotrophic system in rabbits. Anim Sci J, 2009. 80 (2) : p. 157-62.|[4]Kaufmann AM, et al. Aggravation of vasogenic cerebral edema by multiple-dose mannitol. J Neurosurg. 1992;77 (4) :584-589. |[5]Xiao J, et al. Sakaguchi E. Mannitol improves absorption and retention of calcium and magnesium in growing rats. Nutrition. 2013;29 (1) :325-331.|[6]Paczynski RP, et al. Multiple-dose mannitol reduces brain water content in a rat model of cortical infarction. Stroke. 1997;28 (7) :1437-1444.