(±) -10-Hydroxycamptothecin (Standard)
(±) -10-Hydroxycamptothecin (Standard) is the analytical standard of (±) -10-Hydroxycamptothecin. This product is intended for research and analytical applications. (±) -10-Hydroxycamptothecin is an indole alkaloid that inhibits the activity of topoisomerase I and has a broad spectrum of anticancer activity.
Product Specifications
CAS Number
[64439-81-2]
UNSPSC
12352100
Target
Reference Standards; Topoisomerase
Related Pathways
Cell Cycle/DNA Damage; Others
Field of Research
Cancer
Smiles
O=C1C(O)(CC)C2=C(CO1)C(N3CC4=CC5=CC(O)=CC=C5N=C4C3=C2)=O
Molecular Formula
C20H16N2O5
Molecular Weight
364.35
References & Citations
[1]Liu SY, et al. Interaction of several nucleoside triphosphate analogues and 10-hydroxycamptothecin with human DNA topoisomerases. Cancer Res. 1989 Mar 15;49 (6) :1366-70.|[2]Ping YH, et al. Anticancer effects of low-dose 10-hydroxycamptothecin in human colon cancer. Oncol Rep. 2006 May;15 (5) :1273-9.|[3]Fan J, et al. Detection of apoptosis exposed to 10-hydroxycamptothecin in T24 human urinary bladder cancer cells. Zhonghua Wai Ke Za Zhi. 1999 Jan;37 (1) :57-9.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Curated Selection
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