Indole-3-carbinol (Standard)

Indole-3-carbinol (Standard) is the analytical standard of Indole-3-carbinol. This product is intended for research and analytical applications. Indole-3-carbinol (I3C) inhibits NF-κB activity and also is an Aryl hydrocarbon receptor (AhR) agonist, and an inhibitor of WWP1 (WW domain-containing ubiquitin E3 ligase 1) .

Product Specifications

CAS Number

[700-06-1]

UNSPSC

12352100

Hazard Statement

H315, H319

Target

Aryl Hydrocarbon Receptor; E1/E2/E3 Enzyme; Endogenous Metabolite; NF-κB; Reference Standards

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others

Field of Research

Cancer

Purity

98.31

Smiles

OCC1=CNC2=C1C=CC=C2

Molecular Formula

C9H9NO

Molecular Weight

147.18

Precautions

H315, H319

References & Citations

[1]Mohammadi S, et al. Indole-3-carbinol induces G1 cell cycle arrest and apoptosis through aryl hydrocarbon receptor in THP-1 monocytic cell line.J Recept Signal Transduct Res. 2017 Oct;37 (5) :506-514.|[2]Safa M, et al. Indole-3-carbinol suppresses NF-κB activity and stimulates the p53 pathway in pre-B acute lymphoblastic leukemia cells. Tumour Biol. 2015 May;36 (5) :3919-30.|[3]Lee YR, et al. Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway. Science. 2019 May 17;364 (6441) . pii: eaau0159.