Tetrahydropapaverine (hydrochloride)
Tetrahydropapaverine hydrochloride is a tetrahydroisoquinoline (TIQ) compound with inhibitory effects on tryptophan hydroxylase (TPH) (IC50 = 5.7 μM) . Tetrahydropapaverine hydrochloride decreases intracellular serotonin content in murine mastocytoma P815 cells, with an IC50 value of 6.2 μM. Tetrahydropapaverine hydrochloride can be used for studies on potential neurotoxicity in monoaminergic neurons[1][2].
Product Specifications
CAS Number
[6429-04-5]
UNSPSC
12352005
Hazard Statement
H302
Target
Tryptophan Hydroxylase
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Purity
99.84
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL
Smiles
COC1=CC2=C(C=C1OC)CCNC2CC3=CC=C(OC)C(OC)=C3.[H]Cl
Molecular Formula
C20H26ClNO4
Molecular Weight
379.88
Precautions
H302
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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