Rhein-13C4

Rhein-13C4 (Rheic Acid-13C4) is 13C labeled Rhein. Rhein is an anthraquinone compound with anti-inflammatory, antioxidant, and anti-cancer effects[1].

Product Specifications

CAS Number

[1189928-10-6]

Product Name Alternative

Rheic Acid-13C4; Rhubarb yellow-13C4; Monorhein-13C4

UNSPSC

12352005

Target

Apoptosis; Autophagy; Bacterial; Isotope-Labeled Compounds; Reactive Oxygen Species (ROS)

Related Pathways

Anti-infection; Apoptosis; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Inflammation/Immunology

Smiles

O=C1C2=[13C](O)[13CH]=C([13C](O)=O)[13CH]=C2C(C3=CC=CC(O)=C31)=O

Molecular Formula

C11 13C4H8O6

Molecular Weight

288.19

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Heo SK, et al. Rhein augments ATRA-induced differentiation of acute promyelocytic leukemia cells. Phytomedicine. 2018 Oct 1;49:66-74.|[3]Zhao YL, et al. Rhein protects against acetaminophen-induced hepatic and renal toxicity. Food Chem Toxicol. 2011 Aug;49 (8) :1705-10. |[4]Fernand VE, et al. Rhein inhibits angiogenesis and the viability of hormone-dependent and -independent cancer cells under normoxic or hypoxic conditions in vitro. Chem Biol Interact. 2011 Jul 15;192 (3) :220-32.|[5]Hou ML, et al. The Drug-Drug Effects of Rhein on the Pharmacokinetics and Pharmacodynamics of Clozapine in Rat Brain Extracellular Fluid by In Vivo Microdialysis. J Pharmacol Exp Ther. 2015 Oct;355 (1) :125-34.