(2S,4R) -Teneligliptin

(2S,4R) -Teneligliptin is a selective inhibitor of dipeptidyl peptidase IV (DPP-4) . (2S,4R) -Teneligliptin increases the plasma concentration of active glucagon-like peptide-1 (GLP-1), which promotes insulin secretion in response to elevated blood glucose levels, exerting hypoglycemic activity. (2S,4R) -Teneligliptin is promising for research of type 2 diabetes[1].

Product Specifications

CAS Number

[1404559-15-4]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Dipeptidyl Peptidase

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Metabolic Disease

Purity

97.70

Smiles

CC1=NN(C2=CC=CC=C2)C(N3CCN([C@@H]4C[C@@H](C(N5CSCC5)=O)NC4)CC3)=C1

Molecular Formula

C22H30N6OS

Molecular Weight

426.58

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Yoshida T, et al. Discovery and preclinical profile of teneligliptin (3-[ (2S, 4S) -4-[4- (3-methyl-1-phenyl-1H-pyrazol-5-yl) piperazin-1-yl] pyrrolidin-2-ylcarbonyl] thiazolidine) : a highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes[J]. Bioorganic & medicinal chemistry, 2012, 20 (19) : 5705-5719.