Tetrabenazine Metabolite
Tetrabenazine Metabolite is an active metabolite of Tetrabenazine. Tetrabenazine Metabolite is a vesicular monoamine transporter 2 (VMAT2) inhibitor with a high affinity (Ki=13.4 nM) [1]. Tetrabenazine Metabolite is be developed for the treatment of chorea associated with Huntington’s disease and other hyperkinetic disorders[1].
Product Specifications
CAS Number
924854-60-4
Product Name Alternative
(-) -β-Dihydrotetrabenazine; (-) -β-HTBZ
UNSPSC
12352005
Target
Drug Metabolite; Monoamine Transporter
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Solubility
10 mM in DMSO
Smiles
O[C@H]([C@H](CC(C)C)C1)C[C@@]2([H])N1CCC3=C2C=C(OC)C(OC)=C3
Molecular Formula
C19H29NO3
Molecular Weight
319.44
References & Citations
[1]Yao Z, et al. Preparation and evaluation of tetrabenazine enantiomers and all eight stereoisomers of dihydrotetrabenazine as VMAT2 inhibitors. Eur J Med Chem. 2011 May;46 (5) :1841-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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