NPM1 ALK Recombinant Human Active Protein Kinase
The NPM1-ALK protein contains the NPM1 oligomerization motif and the ALK catalytic domain, is constitutively activated through autophosphorylation, and mediates malignant cell transformation by activating downstream effectors including STAT3. NPM1 ALK Recombinant Human Active Protein Kinase is a recombinant NPM1 ALK protein that can be used to study NPM1 ALK-related functions[1].
Product Specifications
UNSPSC
12352211
Target
Anaplastic lymphoma kinase (ALK)
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
[NPM1ALKRecombinantHumanActiveProteinKinase]
References & Citations
[1]Zhang Q, et al. STAT5A is epigenetically silenced by the tyrosine kinase NPM1-ALK and acts as a tumor suppressor by reciprocally inhibiting NPM1-ALK expression. Nat Med. 2007 Nov;13 (11) :1341-8.
Shipping Conditions
Room temperature
Scientific Category
Enzyme
Clinical Information
No Development Reported
Frequently Asked Questions
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