EGFR d746-750/T790M/C797S Recombinant Human Active Protein Kinase
EGFR is a driver of tumorigenesis. EGFR is mainly found in an auto-inhibited, dimerization-incompetent, state at the plasma membrane (PM) . Ligand binding promotes receptor dimerization, which determines a series of structural rearrangements that are conveyed to the cytoplasmic domain allowing the formation of asymmetric dimers between the two juxtaposed catalytic domains. EGFR has multiple mutants. EGFR d746-750/T790M/C797S Recombinant Human Active Protein Kinase is a recombinant EGFR d746-750/T790M/C797S protein that can be used to study EGFR d746-750/T790M/C797S-related functions[1].
Product Specifications
UNSPSC
12352211
Target
EGFR
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
[EGFRd746-750/T790M/C797SRecombinantHumanActiveProteinKinase]
References & Citations
[1]Sigismund S, et al. Emerging functions of the EGFR in cancer. Mol Oncol. 2018 Jan;12 (1) :3-20.
Shipping Conditions
Room temperature
Scientific Category
Enzyme
Clinical Information
No Development Reported
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