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CDK8/CycC Recombinant Human Active Protein Kinase

CDK8 modulates the transcriptional output from distinct transcription factors involved in oncogenic control, including the Wnt/β-catenin pathway, Notch, p53, and transforming growth factor β. Abnormal activity ofCDK8 along with its partner protein cyclin C (CycC) is a common feature of many diseases including colorectal cancer. CDK8/CycC Recombinant Human Active Protein Kinase can be used to study the function of CDK8/CycC[1].

Product Specifications

UNSPSC

12352211

Target

CDK

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Smiles

[CDK8/CycCRecombinantHumanActiveProteinKinase]

References & Citations

[1]Cholko T, et al. A molecular dynamics investigation of CDK8/CycC and ligand binding: conformational flexibility and implication in drug discovery. J Comput Aided Mol Des. 2018 Jun;32 (6) :671-685.

Shipping Conditions

Room temperature

Scientific Category

Enzyme

Clinical Information

No Development Reported

Frequently Asked Questions

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