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ABL1 E255K Recombinant Human Active Protein Kinase

The emergence of mutations in the BCR::ABL1 kinase domain (KD) impairs Imatinib Mesylate binding capacity, thus contributing to Imatinib Mesylate resistance. Identification of these mutations is important for treatment decisions and precision medicine in chronic myeloid leukaemia (CML). ABL1 E255K Recombinant Human Active Protein Kinase is a recombinant ABL1 E255K protein that can be used to study ABL1 E255K-related functions[1].

Product Specifications

UNSPSC

12352211

Target

Bcr-Abl

Related Pathways

Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

[ABL1E255KRecombinantHumanActiveProteinKinase]

References & Citations

[1]Yusoff YM, et al. Identification of novel BCR::ABL1 kinase domain mutation in patients with chronic myeloid leukaemia and imatinib resistance. Malays J Pathol. 2024 Dec;46 (3) :431-439.

Shipping Conditions

Room temperature

Scientific Category

Enzyme

Clinical Information

No Development Reported

Frequently Asked Questions

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