Suc-Leu-Leu-Val-Tyr-AMC (solution)
Suc-Leu-Leu-Val-Tyr-AMC (solution) is a membrane-permeable calpain-specific fluorogenic substrate (Ex/Em = 390/480 nm) [1].Solvent and concentration: DMSO: 20 mM
Product Specifications
CAS Number
[94367-21-2]
Target
Fluorescent Dye; Proteasome
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Others
Smiles
CC(C1=CC=C(NC([C@@H](NC([C@H](C(C)C)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC(CCC(O)=O)=O)=O)=O)=O)CC2=CC=C(O)C=C2)=O)C=C1O3)=CC3=O
Molecular Formula
C40H53N5O10
Molecular Weight
763.89
References & Citations
[1]Roberta L. Debiasi, et al. Reovirus-Induced Apoptosis Is Preceded by Increased Cellular Calpain Activity and Is Blocked by Calpain Inhibitors. J Virol. 1999 Jan; 73 (1) : 695-701.|[2]Tadlock L, et al. Transforming growth factor-beta inhibition of proteasomal activity: a potential mechanism of growth arrest. Am J Physiol Cell Physiol. 2003 Aug;285 (2) :C277-85. Epub 2003 Mar 19.|[3]Gardner RC, et al. Characterization of peptidyl boronic acid inhibitors of mammalian 20 S and 26 S proteasomes and their inhibition of proteasomes in cultured cells. Biochem J. 2000 Mar, 2:447-54.
Shipping Conditions
Room temperature
Scientific Category
Dye Reagents
Clinical Information
No Development Reported
Curated Selection
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