AF-1
AF-1 is a azole-based near-infrared fluorescence diagnostic probe with an emission wavelength of 632 nm. AF-1 selectively accumulates in fungal cell membranes at physiological pH. AF-1 targets and induces Autophagy. AF-1 exhibits antifungal activity and sensitivity to autophagy-related pH[1].
Product Specifications
UNSPSC
12352005
Target
Autophagy; Fluorescent Dye; Fungal
Related Pathways
Anti-infection; Autophagy; Others
Field of Research
Infection
Smiles
FC1=CC(F)=CC=C1C(CN2C=NC=N2)(CN3C=C(N=N3)CCCN4C5=C(C(C)(/C4=C\C=C6CCC/C(C/6=O)=C\C=C7C(C)(C8=C(C=CC=C8)N/7CCCC(N=N9)=CN9CC(O)(CN%10C=NC=N%10)C%11=CC=C(C=C%11F)F)C)C)C=CC=C5)O
Molecular Formula
C62H64F4N14O3
Molecular Weight
1129.26
References & Citations
[1]Yang W, et al. Role of Azole Drugs in Promoting Fungal Cell Autophagy Revealed by an NIR Fluorescence-Based Theranostic Probe. Anal Chem. 2022 May 17;94 (19) :7092-7099.
Shipping Conditions
Room temperature
Scientific Category
Dye Reagents
Clinical Information
No Development Reported
Curated Selection
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