CAQ
CAQ is a near-infrared fluorescent probe based on a curcumin scaffold (Ex/Em = 565/635) . CAQ exhibits high affinity for Aβ1-42 aggregates (Kd = 78.89 nM) and excellent selectivity toward common biomolecules. CAQ’s emission wavelength shows significant solvent dependence. CAQ, by incorporating intramolecular rotation donors and quinoline functional groups, can be used for the specific detection and imaging of Aβ aggregates in Alzheimer's disease[1].
Product Specifications
UNSPSC
12352005
Target
Fluorescent Dye
Related Pathways
Others
Field of Research
Neurological Disease
Smiles
CN(C1=CC=C(C=C1)/C=C/C2=OB(F)(OC(/C=C/C3=CN=C4C=CC=CC4=C3)=C2)F)C
Molecular Formula
C24H21BF2N2O2
Molecular Weight
418.24
References & Citations
[1]Wu J, et al. InVivo Brain Imaging of Amyloid-β Aggregates in Alzheimer's Disease with a Near-Infrared Fluorescent Probe. ACS Sens. 2021 Mar 26;6 (3) :863-870.
Shipping Conditions
Room temperature
Scientific Category
Dye Reagents
Clinical Information
No Development Reported
Curated Selection
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