CAQ

CAQ is a near-infrared fluorescent probe based on a curcumin scaffold (Ex/Em = 565/635) . CAQ exhibits high affinity for Aβ1-42 aggregates (Kd = 78.89 nM) and excellent selectivity toward common biomolecules. CAQ’s emission wavelength shows significant solvent dependence. CAQ, by incorporating intramolecular rotation donors and quinoline functional groups, can be used for the specific detection and imaging of Aβ aggregates in Alzheimer's disease[1].

Product Specifications

UNSPSC

12352005

Target

Fluorescent Dye

Related Pathways

Others

Field of Research

Neurological Disease

Smiles

CN(C1=CC=C(C=C1)/C=C/C2=OB(F)(OC(/C=C/C3=CN=C4C=CC=CC4=C3)=C2)F)C

Molecular Formula

C24H21BF2N2O2

Molecular Weight

418.24

References & Citations

[1]Wu J, et al. InVivo Brain Imaging of Amyloid-β Aggregates in Alzheimer's Disease with a Near-Infrared Fluorescent Probe. ACS Sens. 2021 Mar 26;6 (3) :863-870.