NFC nitro probe 1

NFC nitro probe 1 (compound 18) is an NFC termed probe for Mtb detection. NFC nitro probe 1 (compound 18) shows high potency for R-Mtb and NR-Mtb[1][2].

Product Specifications

CAS Number

[1604838-69-8]

UNSPSC

12171500

Target

Bacterial

Related Pathways

Anti-infection

Field of Research

Infection; Inflammation/Immunology

Smiles

CC1(C)OC2=C3C(OC(C=C3CCC)=O)=C4C(OC([N+]([O-])=O)=C4)=C2CC1

Molecular Formula

C19H19NO6

Molecular Weight

357.36

References & Citations

[1]Ana Negri, et al. Identification of a Mycothiol-Dependent Nitroreductase from Mycobacterium tuberculosis. ACS Infect Dis. 2018 May 11;4 (5) :771-787.|[2]Purong Zheng, et al. Synthetic calanolides with bactericidal activity against replicating and nonreplicating Mycobacterium tuberculosis. J Med Chem. 2014 May 8;57 (9) :3755-72.