Cy3-NO2-Tre

Cy3-NO2-Tre is a nitroreductase-responsive cyanine-based fluorescent probe that specifically labels Mycobacterium tuberculosis (Mtb) . Cy3-NO2-tre generated fluorescence after activation by a specific nitroreductase, Rv3368c, which is conserved in the Mycobacteriaceae. Cy3-NO2-tre effectively imaged mycobacteria within infected host cells, tracked the infection process, and visualized Mycobacterium smegmatis being endocytosed by macrophages (Ex/Em= 540-550/575-625 nm) [1].

Product Specifications

CAS Number

[3012597-48-4]

UNSPSC

12171500

Target

Fluorescent Dye

Related Pathways

Others

Field of Research

Infection

Smiles

CC1(C)C2=CC=CC=C2[N+](CC3=CC=C(C=C3)[N+]([O-])=O)=C1/C=C/C=C4N(C5=CC=CC=C5C/4(C)C)CCCCCC(NC[C@H]6O[C@@H]([C@@H]([C@H]([C@@H]6O)O)O)O[C@H]7O[C@@H]([C@H]([C@@H]([C@H]7O)O)O)CO)=O.[Br-]

Molecular Formula

C48H61BrN4O13

Molecular Weight

981.92

References & Citations

[1]Hong X, et al. From Bench to Clinic: A Nitroreductase Rv3368c-Responsive Cyanine-Based Probe for the Specific Detection of Live Mycobacterium tuberculosis. Anal Chem. 2024 Jan 30;96 (4) :1576-1586.