CAR-2
CAR-2 is a BODIPY-based photosensitizer that induces ferroptosis in photodynamic therapy (PDT) by targeting the endoplasmic reticulum (ER) and lipid droplets (LDs) . CAR-2 exhibits phototoxicity in breast cancer cells with IC50 of 0.01-0.02 μM. CAR-2 exhibits antitumor efficacy in 4T1 xenograft mouse models[1].
Product Specifications
CAS Number
[3030055-40-1]
UNSPSC
12352005
Target
Ferroptosis; Photosensitizer; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer
Smiles
O=C(C1=CC2=C(N(C3=CC=CC=C32)C)C(C4=C5[N+]([B-](F)(N6C4=C(C(I)=C6C)C)F)=C(C(I)=C5C)C)=N1)OC
Molecular Formula
C27H23BF2I2N4O2
Molecular Weight
738.11
References & Citations
[1]Kang K, et al., An endoplasmic reticulum and lipid droplets dual-localized strategy to develop small molecular photosensitizers that induce ferroptosis during photodynamic therapy. Eur J Med Chem. 2025 Mar 15;286:117306.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-D2620/
Scientific Category
Reference compound1
Clinical Information
Phase 1
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