EGTA (tetrasodium)

EGTA tetrasodium is a specific calcium ion chelator. EGTA tetrasodium has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca2+ over Mg2+ (Mg2+ Kd 1-10 mM) . EGTA tetrasodium significantly inhibits the substrate adherence capacity of inflammatory macrophages[1][2].

Product Specifications

CAS Number

[13368-13-3]

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

Biochemical Assay Reagents

Related Pathways

Others

Field of Research

Inflammation/Immunology

Purity

99.93

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(O[Na])CN(CC(O[Na])=O)CCOCCOCCN(CC(O[Na])=O)CC(O[Na])=O

Molecular Formula

C14H20N2Na4O10

Molecular Weight

468.28

Precautions

H302, H315, H319, H335

References & Citations

[1]Harris RA, Hanrahan JW. Effects of EGTA on calcium signaling in airway epithelial cells. Am J Physiol. 1994;267 (5 Pt 1) :C1426-C1434. doi:10.1152/ajpcell.1994.267.5.C1426.|[2]Segura-Egea JJ, Jiménez-Rubio A, Rios-Santos JV, Velasco-Ortega E, Calvo-Gutierrez JR. In vitro inhibitory effect of EGTA on macrophage adhesion: endodontic implications. J Endod. 2003;29 (3) :211-213.