2-Thenoyltrifluoroacetone (Standard)

2-Thenoyltrifluoroacetone (Standard) is the analytical standard of 2-Thenoyltrifluoroacetone. This product is intended for research and analytical applications. 2-Theoyltrifluoroacetone is a chelating agent and mitochondrial electron transfer chain inhibitor, with a IC50 value of 51.5 μM. 2-Thermoyltrifluoroacetone can chelate with various metal ions and has cytotoxicity and anti-tumor activity, which is expected to play an important role in the treatment of mitochondrial dysfunction related diseases[1][2][3].

Product Specifications

CAS Number

[326-91-0]

UNSPSC

12352100

Target

Mitochondrial Metabolism; Reference Standards

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Cancer; Infection; Others

Smiles

O=C(C1=CC=CS1)CC(C(F)(F)F)=O

Molecular Formula

C8H5F3O2S

Molecular Weight

222.19

References & Citations

[1]Ye J, et al. Electron transport chain inhibitors induce microglia activation through enhancing mitochondrial reactive oxygen species production. Exp Cell Res. 2016 Jan 15;340 (2) :315-26. |[2]P.S. Lopes, et al. A new copper (II) complex with 2-thenoyltrifluoroacetone and 2,2-bipyridine: Crystal structure, spectral properties and cytotoxic activity. Journal of Molecular Structure. J. Mol. Struct. 2013. 1034:84-88.|[3]Rahime Eshaghi Malekshah, et al. Crystal structure, molecular docking, and biological activity of the zinc complexes with 2-thenoyltrifluoroacetone and N-donor heterocyclic ligands. J. Mol. Struct. 2017. 1150:155-165|[4]Zhang JG, et al. Thenoyltrifluoroacetone, a potent inhibitor of carboxylesterase activity. Biochem Pharmacol. 2002 Feb 15;63 (4) :751-4.