2'-Deoxyguanosine monohydrate (Standard)

2'-Deoxyguanosine monohydrate (Standard) is the analytical standard of 2'-Deoxyguanosine monohydrate. This product is intended for research and analytical applications. 2'-Deoxyguanosine monohydrate is a nucleoside composed of guanine and deoxyribose, and is one of the basic building blocks of DNA. In the oxidation reaction mediated by singlet oxygen 1O2, the guanine base of 2'-Deoxyguanosine is easily oxidized to generate two major products, 4,8-dihydro-4-hydroxy-8-oxodG and 7,8-dihydro-8-oxodG. The oxidation products of 2'-Deoxyguanosine monohydrate may participate in DNA damage, which may affect gene expression or induce cancer[1].

Product Specifications

CAS Number

[312693-72-4]

UNSPSC

12352100

Target

Endogenous Metabolite; Reference Standards

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Metabolic Disease

Smiles

O[C@H]1C[C@H](N2C=NC3=C2N=C(NC3=O)N)O[C@@H]1CO.O

Molecular Formula

C10H15N5O5

Molecular Weight

285.26

References & Citations

[1]Ravanat JL, et al. Reaction of singlet oxygen with 2'-deoxyguanosine and DNA. Isolation and characterization of the main oxidation products. Chem Res Toxicol. 1995 Apr-May;8 (3) :379-88.