BIBP3226 (TFA)

BIBP3226 TFA is a potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist, with Kis of 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF, respectively. BIBP3226 TFA displays anxiogenic-like effect[1][2].

Product Specifications

CAS Number

[1068148-47-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Neuropeptide Y Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/bibp3226-tfa.html

Purity

99.25

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

FC(C(O)=O)(F)F.OC(C=C1)=CC=C1CNC([C@@H](CCCNC(N)=N)NC(C(C2=CC=CC=C2)C3=CC=CC=C3)=O)=O

Molecular Formula

C29H32F3N5O5

Molecular Weight

587.59

Precautions

H302, H315, H319

References & Citations

[1]Mollereau C, et al. Agonist and antagonist activities on human NPFF (2) receptors of the NPY ligands GR231118 and BIBP3226. Br J Pharmacol. 2001 May;133 (1) :1-4.|[2]Kask A, et al. Anxiogenic-like effect of the neuropeptide Y Y1 receptor antagonist BIBP3226: antagonism with diazepam. Eur J Pharmacol. 1996 Dec 19;317 (2-3) :R3-4.