S- (+) -Ketoprofen-d3

S- (+) -Ketoprofen-d3 ((S) -Ketoprofen-d3) is deuterium labeled S- (+) -Ketoprofen. S- (+) -Ketoprofen is a potent inhibitor of both COX-1 and COX-2 with IC50s of 1.9 and 27 nM, respectively.

Product Specifications

CAS Number

[2747914-77-6]

Product Name Alternative

(S) -Ketoprofen-d3; Dexketoprofen-d3

UNSPSC

12352005

Target

COX; Isotope-Labeled Compounds

Related Pathways

Immunology/Inflammation; Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

O=C(C1=CC=CC=C1)C2=CC([C@H](C([2H])([2H])[2H])C(O)=O)=CC=C2

Molecular Formula

C16H11D3O3

Molecular Weight

257.30

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Palomer A, et al. Modeling cyclooxygenase inhibition. Implication of active site hydration on the selectivity ofketoprofen analogues. J Med Chem. 2000 Jun 1;43 (11) :2280-4.