Buformin (hydrochloride) (Standard)

Buformin (hydrochloride) (Standard) is the analytical standard of Buformin (hydrochloride) . This product is intended for research and analytical applications. Buformin hydrochloride (1-Butylbiguanide hydrochloride), a potent AMPK activator, acts as an orally active biguanide antidiabetic agent. Buformin hydrochloride decreases hepatic gluconeogenesis and lowers blood glucose production in vivo. Buformin hydrochloride also has anti-cancer activities and is applied in cancer study (such as, cervical cancer and breast cancer, et al) [1].

Product Specifications

CAS Number

[1190-53-0]

UNSPSC

12352100

Hazard Statement

H302-H315-H318-H335

Target

AMPK; Reference Standards

Related Pathways

Epigenetics; Others; PI3K/Akt/mTOR

Field of Research

Cancer

Smiles

NC(NC(NCCCC)=N)=N.[H]Cl

Molecular Formula

C6H16ClN5

Molecular Weight

193.68

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Amanda B Parris, et al. Buformin hydrochloride Inhibits the Stemness of erbB-2-overexpressing Breast Cancer Cells and Premalignant Mammary Tissues of MMTV-erbB-2 Transgenic Mice. J Exp Clin Cancer Res|[2]Jing Li, et al. Buformin hydrochloride Suppresses Proliferation and Invasion via AMPK/S6 Pathway in Cervical Cancer and Synergizes With Paclitaxel. Cancer Biol Ther. 2018 Jun 3;19 (6) :507-517.