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Meldonium (Standard)

Meldonium (Standard) is the analytical standard of Meldonium. This product is intended for research and analytical applications. Meldonium (MET-88) functions as a cardioprotective agent by cpmpetetively inhibiting γ-butyrobetaine hydroxylase (BBOX) and carnitine/organic cation transporter type 2 (OCTN2) . Mildronate (Meldonium) exhibits IC50 values of 34-62 μM for human recombinant BBOX and an EC50 of 21 μM for human OCTN2. Meldonium is a fatty acid oxidation inhibitor[1][2].

Product Specifications

CAS Number

76144-81-5

UNSPSC

12352100

Target

Mitochondrial Metabolism; Reference Standards

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Metabolic Disease; Cardiovascular Disease

Purity

99.82

Smiles

C[N+](C)(C)NCCC([O-])=O

Molecular Formula

C6H14N2O2

Molecular Weight

146.19

References & Citations

[1]Dambrova M, et al. Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity. Pharmacol Res. 2016 Nov;113 (Pt B) :771-780.|[2]Jolanta Pupure, et al. Neuroprotective properties of mildronate, a mitochondria-targeted small molecule. Neurosci Lett. 2010 Feb 12;470 (2) :100-5.|[3]Daohui Wang, et al. Meldonium Ameliorates Hypoxia-Induced Lung Injury and Oxidative Stress by Regulating Platelet-Type Phosphofructokinase-Mediated Glycolysis. Front Pharmacol. 2022 Apr 5:13:863451.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, sealed storage, away from light and moisture

Scientific Category

Reference Standards

Available Sizes

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