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Thiethylperazine-d3

Thiethylperazine-d3 is the deuterium labeled Thiethylperazinee (HY-B1794) . Thiethylperazine, a phenothiazine derivate, is an orally active and potent dopamine D2-receptor and histamine H1-receptor antagonist. Thiethylperazine is also a selective ABCC1activator that reduces amyloid-β (Aβ) load in mice. Thiethylperazine has anti-emetic, antipsychotic and antimicrobial effects[1][2][3].

Product Specifications

UNSPSC

12352005

Target

Amyloid-β; Bacterial; Dopamine Receptor; Histamine Receptor; Isotope-Labeled Compounds

Related Pathways

Anti-infection; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling; Others

Field of Research

Infection; Neurological Disease

Smiles

CCSC(C=C1N2CCCN3CCN(C([2H])([2H])[2H])CC3)=CC=C1SC4=C2C=CC=C4

Molecular Formula

C22H26D3N3S2

Molecular Weight

402.63

References & Citations

[1]Czeizel AE, et al. Case-control study of teratogenic potential of thiethylperazine, an anti-emetic drug. BJOG. 2003 May;110 (5) :497-9. |[2]Krohn M, et al. Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice. J Clin Invest. 2011 Oct;121 (10) :3924-31. |[3]Rahbar M, et al. Enhancement of vancomycin activity by phenothiazines against vancomycin-resistant Enterococcus faecium in vitro. Basic Clin Pharmacol Toxicol. 2010 Aug;107 (2) :676-9.

Shipping Conditions

Room temperature

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-B1794S/

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Curated Selection

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