Spermine (tetrahydrochloride)

Spermine tetrahydrochloride is a polyamine nitric oxide donor that can provide nitric oxide to platelets and inhibit platelet activation to a certain extent concentration-dependently. Spermine tetrahydrochloride occurs in mammalian tissues, plants, bacteria, ribosomes and bacteriophage. Spermine tetrahydrochloride inhibits primary human embryo lung fibroblasts in vitro. Spermine is a natural antioxidant and anti-inflammatory agent. Spermine is known to inhibit some bacterial cultures, especially strains of Staphylococcus aureus. Spermine induces neurotoxicity in the striarum dose-dependently. Spermine can reversibly inhibits DNA synthetic response, mixed lymphocyte response and the induction of cytolytic lymphocyte response in primary cultures of murine spleen cells[1][2][3][4][5][6].

Product Specifications

CAS Number

[306-67-2]

UNSPSC

12352211

Hazard Statement

H315, H319

Target

Bacterial; DNA/RNA Synthesis; Endogenous Metabolite; Reactive Oxygen Species (ROS)

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Infection; Inflammation/Immunology; Neurological Disease

Purity

98.10

Solubility

H2O : 50 mg/mL (ultrasonic)

Smiles

NCCCNCCCCNCCCN.Cl.Cl.Cl.Cl

Molecular Formula

C10H30Cl4N4

Molecular Weight

348.18

Precautions

H315, H319

References & Citations

[1]U. Bachrach & B. Reches, (1966) Enzymic assay for spermine and spermidine, Analytical Biochemistry, Volume 17, Issue 1, Volume 17, Issue 1, ISSN 0003-2697. |[2]WANG Jing, et al., (2022) Preliminary Study on Spermine Tetrahydrochloride Inhibition of Platelet Activation[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2022, 24 (3) : 315-319.|[3]Byrd, W. J., et al., (1977) . Synthetic polyamines added to cultures containing bovine sera reversibly inhibit in vitro parameters of immunity. Nature, 267 (5612), 621–623.|[4]Dawson, M., & Dryden, W. F. (1969) . The toxicity of spermine and spermidine to cells in culture. Biochemical pharmacology, 18 (6), 1307–1313.|[5]Løvaas, E., & Carlin, G. (1991) . Spermine: an anti-oxidant and anti-inflammatory agent. Free radical biology & medicine, 11 (5), 455–461.|[6]Otsuki, M., et al., (1995) . In vivo pharmacological study of spermine-induced neurotoxicity. Neuroscience letters, 196 (1-2), 81–84.