Levomepromazine (hydrochloride)

Levomepromazine (Methotrimeprazine) hydrochloride is an orally active antipsychotic compound and Ca2+ release inducer. Levomepromazine inhibits SERCA pump and induces an increase in cytoplasmic Ca2+ levels. Levomepromazine hydrochloride has antagonistic effects on a variety of neurotransmitter receptors, including dopamine, cholinergic, serotonin, and histamine receptors. Levomepromazine hydrochloride can induce adaptive ER stress and autophagy. In addition, Levomepromazine hydrochloride has antiviral, anti-inflammatory, neuroprotective and analgesic, sedative and anti-injurious activities. Levomepromazine hydrochloride can be used in the study psychiatric disorders and relieving nausea and vomiting[1][2][3][4].

Product Specifications

CAS Number

[1236-99-3]

Product Name Alternative

Methotrimeprazine (hydrochloride)

UNSPSC

12352300

Target

5-HT Receptor; Autophagy; Calcium Channel; Dopamine Receptor; Enterovirus; Histamine Receptor

Related Pathways

Anti-infection; Autophagy; GPCR/G Protein; Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Infection; Inflammation/Immunology; Neurological Disease

Smiles

CN(C)C[C@@H](C)CN1C2=CC(OC)=CC=C2SC3=CC=CC=C31.Cl

Molecular Formula

C19H25ClN2OS

Molecular Weight

364.93

References & Citations

[1]Prajapat SK, et al. Methotrimeprazine is a neuroprotective antiviral in JEV infection via adaptive ER stress and autophagy. EMBO Mol Med. 2024 Jan;16 (1) :185-217. |[2]Petts HV, et al. Interactions of morphine and methotrimeprazine in mouse and man with respect to analgesia, respiration and sedation. Br J Anaesth. 1983 May;55 (5) :437-41. |[3]Cox L, et al. Levomepromazine for nausea and vomiting in palliative care. Cochrane Database Syst Rev. 2015 Nov 2; (11) :CD009420.|[4]Sivaraman P, et al. Levomepromazine for schizophrenia. Cochrane Database Syst Rev. 2010 Oct 6; (10) :CD007779.