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Chlorphenoxamine (hydrochloride)

Chlorphenoxamine hydrochloride, an antihistamine and anticholinergic agent is a GPCR antagonist. Chlorphenoxamine hydrochloride inhibits multiple lethal viral diseases, such as SARS-CoV, MERS-CoV, EBOV and malaria. Chlorphenoxamine hydrochloride shows anti-filovirus activity against both EBOV and Marburg virus (MARV) with IC50s of 1.1 μM and 6.2 μM, respectively. Chlorphenoxamine hydrochloride is used for allergic conditions, urticaria, viral diseases and Parkinson’s disease[1][2][3][4][5].

Product Specifications

CAS Number

562-09-4

UNSPSC

12352005

Hazard Statement

H302

Target

Filovirus; Histamine Receptor; Parasite; SARS-CoV

Related Pathways

Anti-infection; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Field of Research

Infection; Neurological Disease; Inflammation/Immunology

Smiles

CC(C1=CC=CC=C1)(C2=CC=C(Cl)C=C2)OCCN(C)C.Cl

Molecular Formula

C18H23Cl2NO

Molecular Weight

340.29

Precautions

P264-P270-P330-P501

References & Citations

[1]ULDALL PR, et al. Chlorphenoxamine hydrochloride in parkinsonism. A controlled trial. Br Med J. 1961 Jun 10;1 (5240) :1649-52.|[2]BAZEX A, et al. Trial treatment of urticaria with chlorphenoxamine. Clinique (Paris) . 1963 Jul-Aug;58:447-50. |[3]Schafer A, et al. Repurposing potential of 1st generation H1-specific antihistamines as anti-filovirus therapeutics. Antiviral Res. 2018 Sep;157:47-56. |[4]Ashraf A, et al. Novel RP-HPLC-DAD approach for simultaneous determination of chlorphenoxamine hydrochloride and caffeine with their related substances. BMC Chem. 2024;18 (1) :133. Published 2024 Jul 19. |[5]Ashraf A, et al. Smart green spectrophotometric estimation and content uniformity testing of chlorphenoxamine HCl and caffeine in bulk forms and combined pharmaceutical formulation. Sci Rep. 2025;15 (1) :9482. Published 2025 Mar 19.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Launched

Frequently Asked Questions

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