Allantoic acid (Standard)

Anagrelide (hydrochloride) (Standard) is the analytical standard of Anagrelide (hydrochloride) . This product is intended for research and analytical applications. Anagrelide hydrochloride (BL4162A) is a potent inhibitor of phosphodiesterase type III (PDE3) (IC50=36 nM) . Anagrelide hydrochloride, an imidazoquinazoline derivative, acts as an inhibitor of platelet aggregation. Anagrelide hydrochloride inhibits bone marrow megakaryocytopoiesis. Anagrelide hydrochloride decreases gastrointestinal stromal tumor (GIST) cell proliferation and promotes their apoptosis in vitro. Anagrelide hydrochloride is a platelet-lowering agent and plays in the antithrombopoietic action[1][2][3].

Product Specifications

CAS Number

[99-16-1]

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

Endogenous Metabolite; Reference Standards

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Others

Purity

99.84

Smiles

NC(NC(C(O)=O)NC(N)=O)=O

Molecular Formula

C4H8N4O4

Molecular Weight

176.13

Precautions

H315, H319, H335

References & Citations

[1]Taherkhani A, et, al. Metabolomic Analysis of Membranous Glomerulonephritis: Identification of a Diagnostic Panel and Pathogenic Pathways. Arch Med Res. 2019 May; 50 (4) :159-169.|[2]Okumura I, et, al. Stereospecificity of conversion of uric acid into allantoic acid by enzymes of Canadida utilis. J Biochem. 1976 May;79 (5) :1013-9.|[3]Cai HL, et, al. Therapeutic efficacy of atypical antipsychotic drugs by targeting multiple stress-related metabolic pathways. Transl Psychiatry. 2017 May 16; 7 (5) :e1130.