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Acefylline (GMP)

Acefylline (Theophyllineacetic acid) (GMP), a xanthine derivative, is an Adenosine Receptor antagonist. Acefylline (GMP) is a peptidylarginine deiminase (PAD) activator. Acefylline (GMP) is also a bronchodilator and cardiac stimulant that inhibits rat lung cAMP phosphodiesterase isoenzymes. Acefylline (GMP) can be used in asthma research[1][2][3].

Product Specifications

CAS Number

652-37-9

Product Name Alternative

Theophyllineacetic acid (GMP) ; Theophylline-7-acetic acid (GMP)

Target

Adenosine Receptor; Phosphodiesterase (PDE) ; Protein Arginine Deiminase

Related Pathways

Epigenetics; GPCR/G Protein; Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Smiles

O=C(O)CN1C=NC(N(C)C(N2C)=O)=C1C2=O

Molecular Formula

C9H10N4O4

Molecular Weight

238.20

References & Citations

[1]Ferretti C, et al. Inhibitory effect of theophylline, theophylline-7-acetic acid, ambroxol and ambroxol-theophylline-7-acetate on rat lung cAMP phosphodiesterase isoenzymes. Int J Tissue React. 1992;14 (1) :31-6. |[2]Méchin MC, et, al. Acefylline activates filaggrin deimination by peptidylarginine deiminases in the upper epidermis. J Dermatol Sci. 2016 Feb;81 (2) :101-6.|[3]Tsvetkova B, Tencheva J, Peikov P. Esterification of 7-theophyllineacetic acid with diethylene glycol monomethyl ether. Acta Pharm. 2006 Jun;56 (2) :251-7. PMID: 16613730.

Shipping Conditions

Room temperature

Scientific Category

GMP Small Molecules

Clinical Information

No Development Reported

Frequently Asked Questions

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