Benzthiazide (Standard)

Benzthiazide (Standard) is the analytical standard of Benzthiazide. This product is intended for research and analytical applications. Benzthiazide is a long-acting diuretic[1] and a hypertension agent. Benzthiazide is an inhibitor of carbonic anhydrase 9 (CA9), with Kis of 8.0, 8.8 and 10 nM for CA9, CA2 and CA1, respectively. Benzthiazide also suppresses proliferation of cancer cells[2].

Product Specifications

CAS Number

[91-33-8]

UNSPSC

12352100

Target

Carbonic Anhydrase; Reference Standards

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Cardiovascular Disease; Cancer

Smiles

O=S(C1=C(Cl)C=C(C2=C1)NC(CSCC3=CC=CC=C3)=NS2(=O)=O)(N)=O

Molecular Formula

C15H14ClN3O4S3

Molecular Weight

431.94

References & Citations

[1]Adler RA, et al. Hypercalciuria in hyperprolactinemic rats: effects of benzthiazide. Metabolism. 1986 Jul;35 (7) :668-72.|[2]Lee HS, et al. Rational drug repositioning guided by an integrated pharmacological network of protein, disease and drug. BMC Syst Biol. 2012 Jul 2;6:80.