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Bendroflumethiazide-d7

Bendroflumethiazide-d7 (Bendrofluazide-d7) is deuterium labeled Bendroflumethiazide (HY-B1363) . Bendroflumethiazide (Bendrofluazide) is an orally available diuretic. Bendroflumethiazide inhibits the electroneutral sodium-chloride symporter located in the apical membrane of the early segment of the distal convoluted tubule and can effectively lower blood pressure. Bendroflumethiazide is used in the study of hypertension and edema. Bendroflumethiazide has an antidiuretic effect in diabetes insipidus[1][2][3].

Product Specifications

Product Name Alternative

Bendrofluazide-d7

UNSPSC

12352005

Target

Isotope-Labeled Compounds; NKCC

Related Pathways

Membrane Transporter/Ion Channel; Others

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Smiles

O=S(C1=C(C(F)(F)F)C=C(C2=C1)NC(C([2H])([2H])C3=C([2H])C([2H])=C([2H])C([2H])=C3[2H])NS2(=O)=O)(N)=O

Molecular Formula

C15H7D7F3N3O4S2

Molecular Weight

428.46

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Tamargo J, et al. Diuretics in the treatment of hypertension. Part 1: thiazide and thiazide-like diuretics. Expert Opin Pharmacother. 2014 Mar;15 (4) :527-47.|[3]Grønbeck L, et al. Mechanism of antidiuresis caused by bendroflumethiazide in conscious rats with diabetes insipidus. Br J Pharmacol. 1998 Feb;123 (4) :737-45.

Shipping Conditions

Room temperature

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-B1363S1/

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

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