Chlortetracycline (hydrochloride)

Chlortetracycline hydrochloride (7-Chlorotetracycline hydrochloride) is an orally active, effective and selectively methanogenic bacteria inhibitor with bactericidal effects. Chlortetracycline hydrochloride is also a antibiotic that acts by inhibiting bacterial protein synthesis. Additionally, Chlortetracycline hydrochloride is a specific and potent calcium ionophore antibiotic, inhibiting binding of aminoacyl-tRNA to ribosomes[1][2][3][4].

Product Specifications

CAS Number

[64-72-2]

Product Name Alternative

7-Chlorotetracycline (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; Bacterial; Parasite

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Purity

95.0

Solubility

DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C(C1=O)=C(O)[C@@H](N(C)C)[C@]2([H])C[C@]3([H])[C@](C)(O)C4=C(C(C3=C(O)[C@@]21O)=O)C(O)=CC=C4Cl)N.[H]Cl

Molecular Formula

C22H24Cl2N2O8

Molecular Weight

515.34

Precautions

H302, H315, H319, H335

References & Citations

[1]Elmund GK, et al. Role of excreted chlortetracycline in modifying the decomposition process in feedlot waste. Bull Environ Contam Toxicol. 1971 Mar-Apr;6 (2) :129-32.|[2]Saling PM, et al. Mouse gamete interactions during fertilization in vitro. Chlortetracycline as a fluorescent probe for the mouse sperm acrosome reaction. J Cell Biol. 1979 Dec;83 (3) :544-55.|[3]Reyes-Contreras C, et al. Methanogenic toxicity evaluation of chlortetracycline hydrochloride[J]. Electronic Journal of Biotechnology, 2015, 18 (6) : 445-450.|[4]Liu D, et al. Synthesis and evaluation of bisulfate/mesylate-conjugated chlortetracycline with high solubility and bioavailability[J]. Acta Pharm. 2020 Dec 1;70 (4) :483-498.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Natural Products

Clinical Information

Launched

Isoform

Tetracycline

Citation 01

Biology (Basel) . 025 Jun 24;14 (7) :755.|BMC Vet Res. 2025 Jul 23;21 (1) :485.|Chemosphere. 2019 Jun:225:378-387.|Saudi Pharm J. 2021 Jun;29 (6) :566-575.|Sci Rep. 2022 Aug 25;12 (1) :14502.