Metacetamol

Metacetamol (AMAP) is a non-hepatotoxic analog of acetaminophen (APAP) . Metacetamol increases glutathione (GSH) in PHH and causes mitochondrial damage. Metacetamol increases total JNK in PHH cell [1].

Product Specifications

CAS Number

[621-42-1]

Product Name Alternative

AMAP

UNSPSC

12352005

Hazard Statement

H315, H319

Target

JNK; Reactive Oxygen Species (ROS)

Related Pathways

Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB

Field of Research

Metabolic Disease

Purity

99.97

Smiles

CC(NC1=CC=CC(O)=C1)=O

Molecular Formula

C8H9NO2

Molecular Weight

151.16

Precautions

H315, H319

References & Citations

[1]Yuchao Xie, et al. Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP) -induced hepatotoxicity in primary human hepatocytes. Toxicol Appl Pharmacol. 2015, 289, 2.