Promethazine (Standard)
Promethazine (Standard) is the analytical standard of Promethazine. This product is intended for research and analytical applications. Promethazine is an orally active histamine receptor antagonist[1]. Promethazine is first-generation antihistamine of the phenothiazine family, shows strong sedative and weak antipsychotic effects[1][2][3][4].
Product Specifications
CAS Number
60-87-7
UNSPSC
12352100
Target
Histamine Receptor; Reference Standards
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling; Others
Field of Research
Endocrinology; Neurological Disease
Smiles
CC(N(C)C)CN1C2=C(C=CC=C2)SC3=CC=CC=C31
Molecular Formula
C17H20N2S
Molecular Weight
284.42
References & Citations
[1]Burt DR, et al. Antischizophrenic drugs: chronic treatment elevates dopamine receptor binding in brain. Science. 1977 Apr 15;196 (4287) :326-8.|[2]Strenkoski-Nix LC, et al. Pharmacokinetics of promethazine hydrochloride after administration of rectal suppositories and oral syrup to healthy subjects. Am J Health Syst Pharm. 2000 Aug 15;57 (16) :1499-505.|[3]Fiorella D, et al. The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of hallucinogenic drugs. I: Antagonist correlation analysis. Psychopharmacology (Berl) . 1995 Oct;121 (3) :347-56.|[4]Seeman P, et al. Dopamine D2 receptor binding sites for agonists. A tetrahedral model. Mol Pharmacol. 1985 Nov;28 (5) :391-9.|[5]Xinyue Tan, et al. Promethazine inhibits proliferation and promotes apoptosis in colorectal cancer cells by suppressing the PI3K/AKT pathway. Biomed Pharmacother. 2021 Nov;143:112174.|[6]Niloofar Amidi, et al. A Behavioral Study of Promethazine Interaction with Analgesic Effect of Diclofenac: Pain Combination Therapy. J Pharmacopuncture. 2020 Mar 31;23 (1) :18-24.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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