Pronethalol (Standard)
Pronethalol (Standard) is the analytical standard of Pronethalol. This product is intended for research and analytical applications. Pronethalol ((±) -Pronethalo) is a non-selective β-adrenergic antagonist. Pronethalol is a potent inhibitor of Sox2 expression. Pronethalol protects against and to reverse Digitalis-induced ventricular arrhythmias and limits the cerebral arteriovenous malformation (AVMs) [1][2].
Product Specifications
CAS Number
54-80-8
UNSPSC
12352100
Target
Adrenergic Receptor; Reference Standards
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Field of Research
Neurological Disease; Cardiovascular Disease
Smiles
OC(CNC(C)C)C1=CC=C2C=CC=CC2=C1
Molecular Formula
C15H19NO
Molecular Weight
229.32
References & Citations
[1]Jiayi Yao, et al. Elevated endothelial Sox2 causes lumen disruption and cerebral arteriovenous malformations. J Clin Invest. 2019 Jun 24;129 (8) :3121-3133.|[2]Aroesty JM, et al. The effects of a beta-adrenergic blocking agent, pronethalol, on digitalis-induced ventricular arrhythmias. Am Heart J. 1966 Apr;71 (4) :503-508.|[3]Aroesty JM, et al. The effects of a beta-adrenergic blocking agent, pronethalol, on digitalis-induced ventricular arrhythmias. Am Heart J. 1966 Apr;71 (4) :503-8.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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