Tetramisole (hydrochloride)
Tetramisole hydrochloride is an orally active, selective inward rectifier potassium channel agonist with an EC50 of approximately 30 μM for the Kir2.1 subunit. Tetramisole hydrochloride is also an anti-nematode agent that blocks neuromuscular transmission by non-competitive depolarization. Tetramisole hydrochloride promotes the forward transport of Kir2.1 channels, hyperpolarizes the resting potential (RP), shortens the action potential duration (APD), inhibits intracellular calcium overload and the PKA signaling pathway, and exerts anti-arrhythmic and anti-myocardial remodeling activities. Tetramisole hydrochloride can be used in cardiac electrophysiology research and research related to myocardial ischemia and heart failure[1][2].
Product Specifications
Product Name Alternative
(±) -Tetramisole hydrochloride; DL-Tetramisole hydrochloride; R-829
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Parasite; PKA; Potassium Channel
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel; Stem Cell/Wnt; TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Infection; Cardiovascular Disease
Purity
99.93
Solubility
DMSO : 10 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
[H]Cl.C12=NC(C3=CC=CC=C3)CN1CCS2
Molecular Formula
C11H13ClN2S
Molecular Weight
240.75
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-B1194/Tetramisole-hydrochloride-SDS-MedChemExpress.pdf
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Inwardly rectifying potassium channel
CAS Number
[5086-74-8]
Available Sizes
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