Tetramisole (hydrochloride)

Tetramisole hydrochloride is an orally active, selective inward rectifier potassium channel agonist with an EC50 of approximately 30 μM for the Kir2.1 subunit. Tetramisole hydrochloride is also an anti-nematode agent that blocks neuromuscular transmission by non-competitive depolarization. Tetramisole hydrochloride promotes the forward transport of Kir2.1 channels, hyperpolarizes the resting potential (RP), shortens the action potential duration (APD), inhibits intracellular calcium overload and the PKA signaling pathway, and exerts anti-arrhythmic and anti-myocardial remodeling activities. Tetramisole hydrochloride can be used in cardiac electrophysiology research and research related to myocardial ischemia and heart failure[1][2].

Product Specifications

CAS Number

[5086-74-8]

Product Name Alternative

(±) -Tetramisole hydrochloride; DL-Tetramisole hydrochloride; R-829

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Parasite; PKA; Potassium Channel

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel; Stem Cell/Wnt; TGF-beta/Smad

Applications

COVID-19-immunoregulation

Field of Research

Infection; Cardiovascular Disease

Purity

99.93

Solubility

DMSO : 10 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

[H]Cl.C12=NC(C3=CC=CC=C3)CN1CCS2

Molecular Formula

C11H13ClN2S

Molecular Weight

240.75

Precautions

H302, H315, H319, H335

References & Citations

[1]Liu Q, et al. Tetramisole is a new IK1 channel agonist and exerts IK1 -dependent cardioprotective effects in rats. Pharmacol Res Perspect. 2022 Aug;10 (4) :e00992.|[2]Nowak LG, et al. Tetramisole and Levamisole Suppress Neuronal Activity Independently from Their Inhibitory Action on Tissue Non-specific Alkaline Phosphatase in Mouse Cortex. Subcell Biochem. 2015;76:239-81.