Mephenytoin-d3

(Rac) -Mephenytoin-d3 is a labelled racemic Mephenytoin. Mephenytoin, an anticonvulsant, is the CYP2C19 and CYP2B6 substrate[1].

Product Specifications

CAS Number

[1185101-86-3]

UNSPSC

12352005

Target

Cytochrome P450; Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Solubility

10 mM in DMSO

Smiles

C(C)C1(C(=O)N(C([2H])([2H])[2H])C(=O)N1)C2=CC=CC=C2

Molecular Formula

C12H11D3N2O2

Molecular Weight

221.27

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Klaassen T, et al. Assessment of urinary mephenytoin metrics to phenotype for CYP2C19 and CYP2B6 activity. Eur J Clin Pharmacol. 2008;64 (4) :387-398.|[3]Relling MV, et al. Mephenytoin phenotyping: lack of haematologic effect and timing of urine collections. Pharmacogenetics. 1991;1 (1) :42-49.