Nitroxoline-d5

Nitroxoline-d5 (8-Hydroxy-5-nitroquinoline-d5) is deuterium labeled Nitroxoline. Nitroxoline (8-Hydroxy-5-nitroquinoline), an antibiotic, is an orally active antibiofilm agent. Nitroxoline reduces the formation and induces the dispersal of Pseudomonas aeruginosa biofilms by chelation of iron and zinc. Nitroxoline can be used for the urinary tract infections and cancer research[1][2][3].

Product Specifications

Product Name Alternative

8-Hydroxy-5-nitroquinoline-d5; 5-Nitro-8-quinolinol-d5

UNSPSC

12352005

Target

Antibiotic; Apoptosis; Autophagy; Bacterial; Isotope-Labeled Compounds

Related Pathways

Anti-infection; Apoptosis; Autophagy; Others

Applications

COVID-19-immunoregulation

Field of Research

Infection; Cancer

Smiles

OC1=C2N=C(C([2H])=C(C2=C(C([2H])=C1[2H])[N+]([O-])=O)[2H])[2H]

Molecular Formula

C9HD5N2O3

Molecular Weight

195.19

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Jin-Guo Yu, et al. Nitroxoline induces cell apoptosis by inducing MDM2 degradation in small-cell lung cancer. Kaohsiung J Med Sci. 2019 Apr;35 (4) :202-208. |[3]A Sobke, et al. The urinary antibiotic 5-nitro-8-hydroxyquinoline (Nitroxoline) reduces the formation and induces the dispersal of Pseudomonas aeruginosa biofilms by chelation of iron and zinc. Antimicrob Agents Chemother. 2012 Nov;56 (11) :6021-5.