Hycanthone (Standard)
Hycanthone (Standard) is the analytical standard of Hycanthone. This product is intended for research and analytical applications. Hycanthone is a thioxanthenone DNA intercalator and inhibits RNA synthesis as well as the DNA topoisomerases I and II. Hycanthone inhibits nucleic acid biosynthesis and inhibits apurinic endonuclease-1 (APE1) by direct protein binding with a KD of 10 nM. Hycanthone is a bioactive metabolite of Lucanthone and has anti-schistosomal agent[1].
Product Specifications
CAS Number
3105-97-3
UNSPSC
12352100
Target
DNA/RNA Synthesis; Parasite; Reference Standards; Topoisomerase
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Others
Field of Research
Infection
Smiles
O=C1C2=C(SC3=C1C=CC=C3)C(CO)=CC=C2NCCN(CC)CC
Molecular Formula
C20H24N2O2S
Molecular Weight
356.48
References & Citations
[1]Mamta D Naidu, et al. Lucanthone and its derivative hycanthone inhibit apurinic endonuclease-1 (APE1) by direct protein binding. PLoS One. 2011;6 (9) :e23679.|[2]Pica Mattoccia L, et al. Effect of hycanthone administered in vivo upon the incorporation of radioactive precursors into macromolecules of Schistosoma mansoni. Mol Biochem Parasitol. 1983 Jun;8 (2) :99-107.|[3]Hahon N, et al. Action of antischistosomal drugs, hycanthone and its analog 1A-4 N-oxide, on viral interferon induction. J Toxicol Environ Health. 1980 Jul;6 (4) :705-12.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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