Thioridazine-d3 2-Sulfone

Thioridazine-d3 2-Sulfone is the deuterium labeled Thioridazine hydrochloride. Thioridazine hydrochloride, an orally active antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine hydrochloride is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with anti-angiogenic effect. Thioridazine hydrochloride shows antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs) [1][2][3][4].

Product Specifications

CAS Number

[1329652-09-6]

UNSPSC

12352005

Target

5-HT Receptor; Apoptosis; Autophagy; Bacterial; Dopamine Receptor; Isotope-Labeled Compounds

Related Pathways

Anti-infection; Apoptosis; Autophagy; GPCR/G Protein; Neuronal Signaling; Others

Field of Research

Cancer; Infection; Neurological Disease

Solubility

10 mM in DMSO

Smiles

C(CC1N(C([2H])([2H])[2H])CCCC1)N2C=3C(SC=4C2=CC=CC4)=CC=C(S(C)(=O)=O)C3

Molecular Formula

C21H23D3N2O2S2

Molecular Weight

405.59

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Tschanz JT, et, al. Atypical antipsychotic drugs block selective components of amphetamine-induced stereotypy. Pharmacol Biochem Behav. 1988 Nov;31 (3) :519-22.|[3]Mu J, et, al. Thioridazine, an antipsychotic drug, elicits potent antitumor effects in gastric cancer. Oncol Rep. 2014 May;31 (5) :2107-14.|[4]Aguilar-Vega L, et, al. Antibacterial properties of phenothiazine derivatives against multidrug-resistant Acinetobacter baumannii strains. J Appl Microbiol. 2021 Apr 22.|[5]Kang S, et, al. Thioridazine induces apoptosis by targeting the PI3K/Akt/mTOR pathway in cervical and endometrial cancer cells. Apoptosis. 2012 Sep;17 (9) :989-97.|[6]Loehr AR, et, al. Targeting Cancer Stem Cells with Differentiation Agents as an Alternative to Genotoxic Chemotherapy for the Treatment of Malignant Testicular Germ Cell Tumors. Cancers (Basel) . 2021 Apr 23;13 (9) :2045.