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Econazole-d6

Econazole-d6 ((±) -Econazol-d6) is the deuterium labeled Econazole. Econazole is an orally active imidazole antifungal agent, as well as a cytochrome P-450 inhibitor and a blocker of calcium and manganese ion uptake. Econazole is active against a variety of fungi and some Gram-positive bacteria, but has no significant activity against Gram-negative bacteria. Econazole can inhibit the synthesis of prostaglandins and can also induce liver damage[1][2][3][4][5].

Product Specifications

CAS Number

2469273-40-1

Product Name Alternative

(±) -Econazol-d6

UNSPSC

12352005

Target

Bacterial; Calcium Channel; Cytochrome P450; Fungal; Isotope-Labeled Compounds

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others

Field of Research

Infection; Metabolic Disease

Smiles

ClC(C([2H])=C1[2H])=C([2H])C([2H])=C1C([2H])([2H])OC(C2=C(C=C(C=C2)Cl)Cl)CN3C=CN=C3

Molecular Formula

C18H9D6Cl3N2O

Molecular Weight

387.72

References & Citations

[1]Köfeler HC, et al. Effect of cytochrome P-450 inhibitors econazole, bifonazole and clotrimazole on prostanoid formation. Br J Pharmacol. 2000 Jul;130 (6) :1241-6. |[2]Mason MJ, et al. Inhibition of Ca2+ transport pathways in thymic lymphocytes by econazole, miconazole, and SKF 96365. Am J Physiol. 1993 Mar;264 (3 Pt 1) :C654-62.|[3]Hill K, et al. Inhibition of TRPM2 channels by the antifungal agents clotrimazole and econazole. Naunyn Schmiedebergs Arch Pharmacol. 2004 Oct;370 (4) :227-37. |[4]Heel RC, et al. Econazole: a review of its antifungal activity and therapeutic efficacy. Drugs. 1978 Sep;16 (3) :177-201.|[5]Liu CF, et al. Antioxidative natural product protect against econazole-induced liver injuries. Toxicology. 2004 Mar 1;196 (1-2) :87-93.

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Frequently Asked Questions

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