(2R,3R) -Diltiazem (hydrochloride)

(2R,3R) -Diltiazem hydrochloride is an isomer of Diltiazem (HY-B0632) hydrochloride. Diltiazem is an orally active L-type Ca2+ channel blocker. Diltiazem shows antihypertensive and antiarrhythmic effects. Diltiazem can be used for the research of cardiac arrhythmia, hypertension, and angina pectoris[1].

Product Specifications

CAS Number

[42399-54-2]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Calcium Channel

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Cardiovascular Disease

Smiles

O=C1[C@@H](OC(C)=O)[C@@H](C2=CC=C(OC)C=C2)SC3=CC=CC=C3N1CCN(C)C.Cl

Molecular Formula

C22H27ClN2O4S

Molecular Weight

450.98

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Yoshinari Niimi, et al. Diltiazem facilitates inactivation of single L-type calcium channels in guinea pig ventricular myocytes. Jpn Heart J. 2003 Nov;44 (6) :1005-14.