Nitisinone-d3
Nitisinone-d3 (NTBC-d3) is deuterium labeled Nitisinone. Nitisinone is an orally active, competitive and reversible 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor with an IC50 of 173 nM. Nitisinone promotes tyrosine accumulation in a dose-dependent manner. nitisinone can be used in studies of hereditary tyrosinemia type 1 (HT-1) (a rare genetic disorder) and albinism[1][2][3][4].
Product Specifications
Product Name Alternative
NTBC-d3; Nitisone-d3; SC0735-d3
UNSPSC
12352005
Target
HPPD; Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Smiles
O=C1C(C(C([2H])C([2H])C1[2H])=O)C(C2=CC=C(C=C2[N+]([O-])=O)C(F)(F)F)=O
Molecular Formula
C14H7D3F3NO5
Molecular Weight
332.25
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Laschi M, et al. Inhibition of para-Hydroxyphenylpyruvate Dioxygenase by Analogues of the Herbicide Nitisinone As a Strategy to Decrease Homogentisic Acid Levels, the Causative Agent of Alkaptonuria. ChemMedChem. 2016 Apr 5;11 (7) :674-8.|[3]Ellis MK, et al. Inhibition of 4-hydroxyphenylpyruvate dioxygenase by 2- (2-nitro-4-trifluoromethylbenzoyl) -cyclohexane-1,3-dione and 2- (2-chloro-4-methanesulfonylbenzoyl) -cyclohexane-1,3-dione. Toxicol Appl Pharmacol. 1995 Jul;133 (1) :12-9. |[4]Onojafe IF, et al. Nitisinone improves eye and skin pigmentation defects in a mouse model of oculocutaneous albinism. J Clin Invest. 2011 Oct;121 (10) :3914-23. |[5]Aktuglu-Zeybek A, et al. Nitisinone: a review. Orphan Drugs: Research and Reviews, 2017, 7.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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