Diquafosol (tetrasodium)
Diquafosol tetrasodium is a P2Y2 receptor agonist that stimulates fluid and mucin secretion on the ocular surface, as a topical treatment of dry eye disease.
Product Specifications
CAS Number
211427-08-6
Product Name Alternative
INS365
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
P2Y Receptor
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Concentration
10mM
Purity
99.0
Solubility
DMSO : 1 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
O[C@H]1[C@@H](O)[C@H](N(C(N2)=O)C=CC2=O)O[C@@H]1COP(OP(OP(OP(OC[C@@H]3[C@@H](O)[C@@H](O)[C@H](N4C(NC(C=C4)=O)=O)O3)(O[Na])=O)(O[Na])=O)(O[Na])=O)(O[Na])=O
Molecular Formula
C18H22N4Na4O23P4
Molecular Weight
878.23
Precautions
H302, H315, H319, H335
References & Citations
[1]Lee JH, et al. Comparison of cytotoxicities and wound healing effects of diquafosol tetrasodium and hyaluronic acid on human corneal epithelial cells. Korean J Physiol Pharmacol. 2017 Mar;21 (2) :189-195.|[2]Fujihara T, et al. Improvement of corneal barrier function by the P2Y (2) agonist INS365 in a rat dry eye model. Invest Ophthalmol Vis Sci. 2001 Jan;42 (1) :96-100.|[3]Fujihara T, et al. INS365 suppresses loss of corneal epithelial integrity by secretion of mucin-like glycoprotein in a rabbit short-term dry eye model. J Ocul Pharmacol Ther. 2002 Aug;18 (4) :363-70.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
P2Y2 Receptor
Available Sizes
Frequently Asked Questions
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