Tetrabenazine-d7

Tetrabenazine-d7 (TBZ-d7-d7) is deuterium labeled Tetrabenazine. Tetrabenazine (Ro 1-9569) is a reversible inhibitor of the vesicular monoamine transporter VMAT2 with the Kd value of 1.34 nM. Tetrabenazine can be used for research on diseases related to hyperactive movement disorders such as Huntington's disease[1][2][3][4].

Product Specifications

CAS Number

[2701977-99-1]

Product Name Alternative

TBZ-d7-d7; Ro 1-9569-d7

UNSPSC

12352005

Target

Isotope-Labeled Compounds; Monoamine Transporter

Related Pathways

Membrane Transporter/Ion Channel; Others

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

O=C1[C@H](CN2[C@@]([H])(C1)C3=C(CC2)C=C(OC)C(OC)=C3)CC([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H]

Molecular Formula

C19H20D7NO3

Molecular Weight

324.47

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]J C Shih, et al. Ketanserin and tetrabenazine abolish aggression in mice lacking monoamine oxidase A. Brain Res. 1999 Jul 24;835 (2) :104-12.|[3]Jankovic, J. and J. Beach, Long-term effects of tetrabenazine in hyperkinetic movement disorders. Neurology, 1997. 48 (2) : p. 358-62.|[4] Nobue Kitanaka, et al. Tetrabenazine, a vesicular monoamine transporter-2 inhibitor, attenuates morphine-induced hyperlocomotion in mice through alteration of dopamine and 5-hydroxytryptamine turnover in the cerebral cortex. Pharmacol Biochem Behav. 2018 Sep;172:9-16. doi: 10.1016/j.pbb.2018.07.002. Epub 2018 Jul 12.|[5]Kenney, C., C. Hunter, and J. Jankovic, Long-term tolerability of tetrabenazine in the treatment of hyperkinetic movement disorders. Mov Disord, 2007. 22 (2) : p. 193-7.|[6]S J Podurgiel, et al. The vesicular monoamine transporter (VMAT-2) inhibitor tetrabenazine induces tremulous jaw movements in rodents: implications for pharmacological models of parkinsonian tremor. Neuroscience. 2013 Oct 10;250:507-19. doi: 10.1016/j.neuroscience.2013.07.008. Epub 2013 Jul 15. |[7]Ondo, W.G., P.A. Hanna, and J. Jankovic, Tetrabenazine treatment for tardive dyskinesia: assessment by randomized videotape protocol. Am J Psychiatry, 1999. 156 (8) : p. 1279-81.